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Shrey Sindhwani: Revolutionizing Nanotechnology in Medicine

Shrey Sindhwani: Revolutionizing Nanotechnology in Medicine – Nanotechnology has emerged as a groundbreaking field with the potential to revolutionize medicine. One individual who has made significant contributions to this field is Shrey Sindhwani. Through his research and innovative approaches, Sindhwani has paved the way for advancements in nanoparticle delivery systems, tumor imaging, and diagnostic devices. In this article, we will delve into the remarkable work of Shrey Sindhwani, exploring his groundbreaking research and its implications for the future of medicine.

The Entry of Nanoparticles into Solid Tumors

Sindhwani, along with his colleagues, conducted pioneering research on the entry of nanoparticles into solid tumors. Their studies focused on understanding the mechanisms by which nanoparticles can penetrate the tumor microenvironment and deliver therapeutic agents effectively. By coating the nanoparticles with ligands, they were able to enhance their delivery to cancer cells within solid tumors.

Through a combination of quantitative analysis and mass spectrometry, Sindhwani and his team developed a method to predict the in vivo fate of nanomaterials. This approach, based on supervised learning and mass spectrometry, provides valuable insights into the behavior and distribution of nanoparticles within biological systems.

Three-Dimensional Imaging of Nanoparticle Distribution

One of Sindhwani’s significant contributions is the development of a three-dimensional imaging technique to map nanoparticle distribution in intact tissues. This groundbreaking approach allows researchers to visualize and analyze the spatial distribution of nanoparticles, providing crucial information for optimizing their delivery to specific areas of interest.

To overcome the challenges posed by tissue transparency, Sindhwani and his team utilized metal nanoparticle labeling. This technique enables the imaging of transparent tissues, offering a non-invasive and high-throughput method for structural analysis.

Nanotechnology for Modern Medicine

Sindhwani’s research has paved the way for the clinical translation of nanotechnology in medicine. By harnessing the unique properties of nanoparticles, such as their small size and surface modifications, Sindhwani aims to develop novel therapeutic approaches for various diseases. His work focuses on improving drug delivery systems, diagnostic devices, and imaging techniques to enhance patient outcomes.

Assessing Micrometastases as a Target for Nanoparticles

In collaboration with his colleagues, Sindhwani has explored the potential of nanoparticles in targeting micrometastases. By employing 3D microscopy and machine learning, they were able to assess the feasibility of using nanoparticles for the early detection and treatment of cancer metastasis. This research opens up new avenues for personalized medicine and improved patient care.

Specific Endothelial Cells and Nanoparticle Entry into Solid Tumors

Sindhwani and his team have made significant progress in understanding the role of specific endothelial cells in nanoparticle entry into solid tumors. By elucidating the underlying mechanisms, they aim to develop targeted therapies that can enhance the delivery of nanoparticles to tumor sites. This research has the potential to revolutionize cancer treatment and improve patient outcomes.

Clarifying Intact 3D Tissues for Structural Analysis

A notable achievement in Sindhwani’s research is the development of a microfluidic chip for high-throughput structural analysis of intact 3D tissues. This innovative approach allows for the clear visualization and analysis of tissue structures, providing valuable insights into their composition and organization. By combining microfluidics and imaging techniques, Sindhwani has opened up new possibilities for studying complex biological systems.

Passive Clearing for 3D Optical Imaging of Nanoparticles

Sindhwani and his team have also explored the use of passive clearing techniques for 3D optical imaging of nanoparticles in intact tissues. By optimizing the optical properties of tissues, they were able to improve the imaging depth and resolution, enabling the visualization of nanoparticle distribution in greater detail. This research has implications for the development of advanced imaging techniques in various biomedical applications.

Engineering Steps for Mobile Point-of-Care Diagnostic Devices

In collaboration with his colleagues, Sindhwani has contributed to the development of engineering steps for mobile point-of-care diagnostic devices. These devices have the potential to revolutionize healthcare by providing rapid and accurate diagnostic results at the bedside. Sindhwani’s research focuses on enhancing the sensitivity, specificity, and portability of these devices, making them accessible to a wide range of healthcare settings.

Electrochemical Growth of Nanowires and Nanobelt-Like Structures

Sindhwani’s early research focused on the electrochemical growth of nanowires and nanobelt-like structures. By exploring the synthesis, characterization, and embedding of enzymes within these structures, Sindhwani aimed to develop novel materials for various applications. His work in this area laid the foundation for his later research in nanomedicine and biomedical engineering.

Liposome Imaging in Optically Cleared Tissues

In collaboration with his colleagues, Sindhwani has made significant strides in liposome imaging in optically cleared tissues. This technique enables the visualization of liposomes, which are lipid-based nanoparticles, within transparent tissues. By utilizing this imaging approach, researchers can gain insights into the distribution and behavior of liposomes, facilitating the development of improved drug delivery systems.

Subtherapeutic Photodynamic Treatment for Tumor Nanomedicine Delivery

Another notable contribution by Sindhwani is the exploration of subtherapeutic photodynamic treatment for tumor nanomedicine delivery. This approach leverages photodynamic therapy, a technique that uses light to activate photosensitizing agents, to enhance the delivery of nanomedicines to tumor sites. By overcoming the barriers posed by the tumor microenvironment, this research has the potential to improve the efficacy of cancer treatments.

The Exit of Nanoparticles from Solid Tumors

In a recent study, Sindhwani and his colleagues investigated the exit of nanoparticles from solid tumors. By understanding the clearance mechanisms, they aim to design nanoparticles that can efficiently exit the tumor microenvironment, preventing their accumulation and potential toxicity. This research contributes to the development of safer and more effective nanoparticle-based therapies.


The entry of nanoparticles into solid tumours

S Sindhwani, AM Syed, J Ngai, BR Kingston, L Maiorino, J Rothschild, …
Nature materials 19 (5), 566-575
1087 2020
Quantifying the ligand-coated nanoparticle delivery to cancer cells in solid tumors

Q Dai, S Wilhelm, D Ding, AM Syed, S Sindhwani, Y Zhang, YY Chen, …
ACS nano 12 (8), 8423-8435
474 2018
Supervised Learning and Mass Spectrometry Predicts the in Vivo Fate of Nanomaterials

J Lazarovits, S Sindhwani, AJ Tavares, Y Zhang, F Song, J Audet, …
ACS nano 13 (7), 8023-8034
113 2019
Three-dimensional optical mapping of nanoparticle distribution in intact tissues

S Sindhwani, AM Syed, S Wilhelm, DR Glancy, YY Chen, M Dobosz, …
ACS nano 10 (5), 5468-5478
92 2016
Nanotechnology for modern medicine: next step towards clinical translation

S Sindhwani, WCW Chan
Journal of Internal Medicine 290 (3), 486-498
87 2021
Three-dimensional imaging of transparent tissues via metal nanoparticle labeling

AM Syed, S Sindhwani, S Wilhelm, BR Kingston, DSW Lee, …
Journal of the American Chemical Society 139 (29), 9961-9971
73 2017
Assessing micrometastases as a target for nanoparticles using 3D microscopy and machine learning

BR Kingston, AM Syed, J Ngai, S Sindhwani, WCW Chan
Proceedings of the National Academy of Sciences 116 (30), 14937-14946
64 2019
Specific endothelial cells govern nanoparticle entry into solid tumors

BR Kingston, ZP Lin, B Ouyang, P MacMillan, J Ngai, AM Syed, …
ACS nano 15 (9), 14080-14094
63 2021
Clarifying intact 3D tissues on a microfluidic chip for high-throughput structural analysis

YY Chen, PN Silva, AM Syed, S Sindhwani, JV Rocheleau, WCW Chan
Proceedings of the National Academy of Sciences 113 (52), 14915-14920
60 2016
Exploring passive clearing for 3D optical imaging of nanoparticles in intact tissues

S Sindhwani, AM Syed, S Wilhelm, WCW Chan
Bioconjugate Chemistry 28 (1), 253-259
52 2017
Engineering steps for mobile point-of-care diagnostic devices

A Malekjahani, S Sindhwani, AM Syed, WCW Chan
Accounts of chemical research 52 (9), 2406-2414
47 2019
Parametric study on dimensional control of ZnO nanowalls and nanowires by electrochemical deposition

D Pradhan, S Sindhwani, KT Leung
Nanoscale research letters 5, 1727-1736
47 2010
Template-free electrochemical growth of single-crystalline zinc nanowires at an anomalously low temperature

D Pradhan, S Sindhwani, KT Leung
The Journal of Physical Chemistry C 113 (36), 15788-15791
39 2009
Electrochemical growth of ZnO nanobelt-like structures at 0 C: synthesis, characterization, and in-situ glucose oxidase embedment

D Pradhan, Z Su, S Sindhwani, JF Honek, KT Leung
The Journal of Physical Chemistry C 115 (37), 18149-18156
38 2011
Subtherapeutic photodynamic treatment facilitates tumor nanomedicine delivery and overcomes desmoplasia

M Overchuk, KM Harmatys, S Sindhwani, MA Rajora, A Koebel, …
Nano Letters 21 (1), 344-352
29 2020
Liposome imaging in optically cleared tissues

AM Syed, P MacMillan, J Ngai, S Wilhelm, S Sindhwani, BR Kingston, …
Nano Letters 20 (2), 1362-1369
29 2020
The exit of nanoparticles from solid tumours

LNM Nguyen, ZP Lin, S Sindhwani, P MacMillan, SM Mladjenovic, …
Nature Materials 22 (10), 1261-1272
9 2023
Making vessels more permeable

AM Syed, S Sindhwani, WCW Chan
Nature Biomedical Engineering 1 (8), 629-631
8 2017
Toward Predicting Nanoparticle Distribution in Heterogeneous Tumor Tissues

P MacMillan, AM Syed, BR Kingston, J Ngai, S Sindhwani, ZP Lin, …
Nano Letters 23 (15), 7197-7205
2 2023
Community-driven online initiatives have reshaped scientific engagement

JPK Armstrong, I de Lázaro, NJ Kirkland, W Poon, S Sindhwani
Nature Reviews Materials 6 (11), 963-965
1 2021

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Shrey Sindhwani’s research in nanotechnology has revolutionized the field of medicine. Through his groundbreaking work on nanoparticle delivery systems, tumor imaging, and diagnostic devices, Sindhwani has paved the way for advancements in personalized medicine, targeted therapies, and improved patient outcomes. His innovative approaches and contributions continue to shape the future of nanomedicine, offering new possibilities for the diagnosis, treatment, and prevention of diseases.


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